CALL FOR PAPERS Chronic Kidney Disease and Fibrosis TGF- /Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1 expression
نویسندگان
چکیده
Benaya Rozen-Zvi, Tomoko Hayashida, Susan C. Hubchak, Christian Hanna, Leonidas C. Platanias, and H. William Schnaper Division of Kidney Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann & Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, Illinois; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; and Department of Nephrology and Hypertension Rabin Medical Center, Petah-Tikva, Israel
منابع مشابه
TGF-β/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1α expression.
Transforming growth factor (TGF)-β is a major mediator of kidney fibrosis. In the past decade it was recognized that, besides canonical Smad signaling, many other signaling pathways participate in the process of TGF-β-induced fibrogenesis. One such pathway involves mammalian target of rapamycin complex (mTORC)1. We recently reported that the hypoxia-inducible factor (HIF)-1 is essential for TGF...
متن کاملFrom TOR and SMAD, why HIF-1α can be bad.
TRANSFORMING GROWTH FACTOR (TGF)is a pleiotropic cytokine that regulates cell growth, differentiation, proliferation, immune response, and extracellular matrix remodeling; it plays a pivotal role in fibrosis in multiple organs (1). TGFsignals via type I (T RI) and type II (T RII) receptors. Binding of TGFto T RII, a serine/threonine kinase, recruits T RI to form a heteromeric ligand-receptor co...
متن کاملInterdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression.
Increasing evidence suggests that chronic kidney disease may develop following acute kidney injury and that this may be due, in part, to hypoxia-related phenomena. Hypoxia-inducible factor (HIF) is stabilized in hypoxic conditions and regulates multiple signaling pathways that could contribute to renal fibrosis. As transforming growth factor (TGF)-β is known to mediate renal fibrosis, we propos...
متن کاملThe orphan nuclear receptor SHP attenuates renal fibrosis.
The accumulation of extracellular matrix proteins is a common feature of fibrotic kidney diseases. Accumulating evidence suggests that TGF-beta and plasminogen activator inhibitor type 1 (PAI-1) promote the development of renal fibrosis by stimulating the generation and inhibiting the removal of matrix proteins. The small heterodimer partner (SHP) represses PAI-1 expression in the liver by inhi...
متن کاملThe effect of aerobic exercise on MMP-2 / miR-21 signaling pathway of cardiac fibrosis in elderly rats
Background :The concept of survival has changed since the twentieth century to guarantee quality of life in the twenty-first century (1). Aging is associated with a certain degree of interstitial fibrosis, which progresses to heart failure. Therefore, finding new and practical methods is an important and necessary help to reduce heart tissue fibrosis in the elderly (2). Providing mechanisms by ...
متن کامل